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KMID : 0988420010130030258
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Journal of Dental Science (C.N.U.)
2001 Volume.13 No. 3 p.258 ~ p.267
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The Effect of Absorbable Membrane (BioMesh^®) on Bone Regeneration in Rabbit
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Abstract
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The purpose of the present study was to investigate the effect of absorbable membrane (BioMesh^®) on bone regeneration in the rabbit by evaluating biodegradability, biocompatibility and bone regenerative capacity. Eight rabbits, weighing about 2kg, were used. Two bone defects, 8 mm in diameter and 7 mm in depth, were made. In the experimental group, the bone defect was covered with BioMesh^® absorbable membrane. In the control group, induced spontaneous healing. The rabbits were sacrificed at 2, 4, 6, and 8 weeks after the operation. Radiographic and microscopic examination were performed. Results obtained were as follows:
After 2 weeks, proliferation of the fibrous tissue was observed in the control group, but the newly formed cartilage and more active bone formation were noted in the experimental group. After 4 weeks, the new bone formation appeared in the control group, and in the experimental group, the bone trabeculi were densely aligned and matured. After 6 weeks, complete resorption of the BioMesh^® membrane occurred in the experimental group. Both experimental and control group acquired dense osseous coverage, after 8 weeks.
These results suggest that the BioMesh^® absorbable membrane contributes new bone formation by guiding bone regeneration in the early stage.
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